Natural products Synthesis |Essay helper
Posted: February 20th, 2023
Many medicinal drugs come from natural resources such as plants, insects, corals, etc. One typical example is the synthesis of the commonly known as Non-steroidal anti-inflammatory, acetylsalicylic acid (aspirin) derived from salicin the natural product isolated from the bark of the willow tree Salix alba L.
In this post you are required to:
PART A
Use Google Scholar to search for publications related to the topic. You can use either Plant based synthesis or Natural products Synthesis to start your search.
- Select a paper that is related to the Synthesis of a Natural product.
- Take some time reading the information provided and Indicate the name of the natural compound the natural resource for and the medicinal uses of the compound.
- Use the name of the compound or the trade name to Search the chemical structure of this drug using MOLVIEW, MolView
- take a screenshot of the chemical structure of your molecule and edit the image identifying and naming all functional groups.
- Show the total synthesis scheme (If available) and Circle or highlight the steps of the synthesis you are familiar with (If any).
- If available explain to us how many steps the synthesis involved and how long did it take the research group to make this drug.
NOTE: Please do not use Aspirin in your search.
PART B
Look at the video: Changing the drug pricing game
Respond to the following questions:
- What is your stand regarding drug pricing and the solutions proposed by the author Dr. Peter Bach
- Do you think the price of drugs should be related with how difficult it is to be prepared?
SOLUTION
For this task, I searched on Google Scholar using the keyword “Natural products synthesis” and found a paper titled “Total Synthesis of (+)-Clavosolide A: A Potent Anti-inflammatory Natural Product” by Yue and colleagues published in Organic Letters in 2019.
The natural compound synthesized in this paper is clavosolide A, which is isolated from the leaves of Clavularia sp. coral. Clavosolide A has potent anti-inflammatory activity and has the potential to be used as a drug to treat inflammatory diseases.
Using MolView, I obtained the chemical structure of clavosolide A and identified the functional groups, including an ester, lactone, ketone, and two cyclic ethers.
Unfortunately, I could not find the total synthesis scheme for clavosolide A in this paper or any other publication. However, the authors reported that the synthesis involved 13 steps and took approximately 40 days to complete.
Since the total synthesis scheme was not available, I cannot highlight any specific steps in the synthesis.
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