What is the first-line therapy for osteoarthritis and the mechanism of action|Legit essays

Posted: February 20th, 2023

Sally is a 50-year-old female who has been a jogger for several years. She has recently been diagnosed with osteoarthritis. She has been taking ibuprofen for 3 months but states that “it does not help” and hurts her stomach. The health care provider prescribes celecoxib (Celebrex) 100 mg orally twice a day.

  1. What is the first-line therapy for osteoarthritis and the mechanism of action?
  2. Sally expresses concern about all the recent news about heart problems and celecoxib (Celebrex). What information should be included in a teaching plan to help her understand about taking celecoxib and the benefits and risks?
  3. Ibuprofen and celecoxib are both nonsteroidal anti-inflammatory drugs. Explain how they are similar and different


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  • Your initial post should be at least 500 words, formatted and cited in current APA style with support from at least 2 academic sources.


  1. First-line therapy for osteoarthritis and mechanism of action: The first-line therapy for osteoarthritis typically includes non-pharmacologic interventions such as exercise, weight loss, and physical therapy. However, if these interventions are not sufficient to manage symptoms, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is typically recommended. NSAIDs work by inhibiting the activity of cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins that cause pain, inflammation, and fever.
  2. Teaching plan on Celecoxib (Celebrex): It is important to explain to Sally that Celecoxib is an NSAID that is effective in relieving pain and inflammation associated with osteoarthritis. However, like all NSAIDs, it has a risk of causing gastrointestinal side effects such as stomach ulcers and bleeding, particularly in people with a history of gastrointestinal problems. Additionally, there have been concerns about the cardiovascular risks of Celecoxib, particularly at higher doses or in people with a history of heart disease. It is important to emphasize to Sally that she should only take the prescribed dose and duration of Celecoxib, and report any new or worsening symptoms to her healthcare provider immediately.
  3. Comparison of Ibuprofen and Celecoxib: Ibuprofen and Celecoxib are both NSAIDs, but they have some differences in terms of their mechanism of action, dosage, and side effect profile. Ibuprofen inhibits both COX-1 and COX-2 enzymes, while Celecoxib selectively inhibits COX-2 enzyme, which is responsible for inflammation and pain. Celecoxib is generally considered to have a lower risk of causing gastrointestinal side effects than Ibuprofen, but it may have a higher risk of cardiovascular side effects, particularly at higher doses or in people with a history of heart disease. It is important for Sally to discuss the risks and benefits of these medications with her healthcare provider to determine the most appropriate treatment plan for her.

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